Some phenomena, such as deep sky objects, are very demanding on the knowledge, skills and equipment. We need to be clear about the different levels of complexity so that you know which photos you can take and which are beyond your reach. What had previously been possible to achieve only with scientific methods and very specialized equipment is now within the reach of everyday photographers with suitable equipment. With the technological progress of cameras today, modern DSLR and mirrorless cameras make it far easier than before to capture the beauty of the night sky. How Hard Is It to Photograph Star Trails? Merging several photos versus taking one super-long exposure.How long of an exposure is long enough?.Challenge 2: Setting the Right Exposure Values.Circular lines and shapes: A strong visual anchor.Best Conditions for Star Trail Photography.How Hard Is It to Photograph Star Trails?.PD-L1 chemotherapy durvalumab gastric cancer gastroesophageal junction cancer immune checkpoint inhibitors immunotherapy neoadjuvant-adjuvant resectable. Clinical trial registration: NCT04592913 (). The planned sample size is 900 patients, the primary end point is event-free survival and safety and tolerability will be evaluated. We describe the rationale for and the design of MATTERHORN, a randomized, double-blind, placebo-controlled, phase III study investigating the efficacy and safety of neoadjuvant-adjuvant durvalumab and FLOT chemotherapy followed by adjuvant durvalumab monotherapy in patients with resectable gastric/gastroesophageal junction cancer. Accumulating evidence indicates that ICIs combined with FLOT chemotherapy improve clinical outcomes in patients with advanced or metastatic cancer. Early-phase clinical studies support further clinical development of the immune checkpoint inhibitor (ICI) durvalumab, an anti-PD-L1 antibody, in patients with gastric/gastroesophageal junction cancer. Standard-of-care for resectable gastric/gastroesophageal junction cancer includes surgery and neoadjuvant-adjuvant 5-fluorouracil-leucovorin-oxaliplatin-docetaxel (FLOT) chemotherapy.
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